Annual report pursuant to Section 13 and 15(d)

Stock-Based Compensation - Stock-Based Compensation Expense (Detail)

v3.6.0.2
Stock-Based Compensation - Stock-Based Compensation Expense (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Total stock-based compensation expense $ 15,057 $ 11,730 $ 9,200
Research and development [Member]      
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Total stock-based compensation expense 6,463 6,444 5,064
General and administrative [Member]      
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Total stock-based compensation expense $ 8,594 $ 5,286 $ 4,136