Annual report pursuant to Section 13 and 15(d)

Major Customers, Partnerships and Strategic Alliances - Revenues Recognized under Agreement (Detail)

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Major Customers, Partnerships and Strategic Alliances - Revenues Recognized under Agreement (Detail) - USD ($)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Bioverativ Inc [Member]      
Revenues:      
Recognition of upfront fee $ 2,321,000 $ 6,176,000 $ 5,313,000
Royalty revenues 0    
Research services 6,565,000 7,769,000 7,751,000
Total 8,886,000 13,945,000 13,064,000
Shire AG [Member]      
Revenues:      
Recognition of upfront fee 2,181,000 2,167,000 2,167,000
Recognition of milestone     1,000,000
Research services 1,096,000 13,584,000 22,765,000
Total 3,277,000 15,751,000 25,932,000
Sigma-Aldrich Corporation [Member]      
Revenues:      
Royalty revenues 137,000 390,000 344,000
License fee and milestone revenues 1,140,000 4,463,000 448,000
Total $ 1,277,000 $ 4,853,000 $ 792,000