Annual report pursuant to Section 13 and 15(d)

Major Customers, Partnerships and Strategic Alliances - Agreement with Sigma-Aldrich Corporation - Additional Information (Detail)

v3.6.0.2
Major Customers, Partnerships and Strategic Alliances - Agreement with Sigma-Aldrich Corporation - Additional Information (Detail) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Oct. 31, 2009
Jul. 31, 2007
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Common stock issued under license agreement         $ 93,796
Research and development     $ 65,618 $ 67,198 56,974
Sigma-Aldrich Corporation [Member]          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Research program to develop laboratory research reagents   3 years      
Upfront license fee $ 20,000        
Public offering, common stock shares issued 636,133        
Reduced royalty rate 10.50%        
Funding available under the amended agreement $ 25,000        
Sigma-Aldrich Corporation [Member] | Upfront license fee [Member]          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Upfront license fee 15,100        
Common stock issued under license agreement $ 4,900        
Sigma-Aldrich Corporation [Member] | License agreement terms [Member]          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Revenues under agreement     5,000    
Research and development     $ 100 $ 400 $ 100