Quarterly report pursuant to Section 13 or 15(d)

Major Customers, Partnerships and Strategic Alliances - Revenues Recognized under Agreement (Detail)

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Major Customers, Partnerships and Strategic Alliances - Revenues Recognized under Agreement (Detail) - USD ($)
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Bioverativ Inc [Member]    
Revenues:    
Recognition of upfront fee $ 442,000 $ 608,000
Royalty revenues 0  
Research services 1,709,000 2,031,000
Total 2,151,000 2,639,000
Shire AG [Member]    
Revenues:    
Recognition of upfront fee 583,000 542,000
Research services 107,000 429,000
Total 690,000 971,000
Sigma-Aldrich Corporation [Member]    
Revenues:    
Royalty revenues 32,000 12,000
License fee revenues 267,000 7,000
Total $ 299,000 $ 19,000