Quarterly report pursuant to Section 13 or 15(d)

Major Customers, Partnerships and Strategic Alliances - Revenues Recognized under Agreement (Detail)

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Major Customers, Partnerships and Strategic Alliances - Revenues Recognized under Agreement (Detail) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Bioverativ Inc [Member]        
Revenues:        
Recognition of upfront fee $ 442,000 $ 608,000 $ 884,000 $ 1,216,000
Royalty revenues     0  
Research services 3,068,000 1,894,000 4,777,000 3,925,000
Total 3,510,000 2,502,000 5,661,000 5,141,000
Shire AG [Member]        
Revenues:        
Recognition of upfront fee 583,000 541,000 1,167,000 1,083,000
Research services 3,000 363,000 110,000 792,000
Total 586,000 904,000 1,277,000 1,875,000
Sigma-Aldrich Corporation [Member]        
Revenues:        
Royalty revenues 19,000 49,000 50,000 61,000
License fee revenues   63,000 267,000 70,000
Total $ 19,000 $ 112,000 $ 317,000 $ 131,000