April 30, 2008

Sangamo BioSciences Reports First Quarter 2008 Financial Results

RICHMOND, Calif., April 30, 2008 /PRNewswire-FirstCall via COMTEX News Network/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) today reported first quarter 2008 financial results and accomplishments.

For the first quarter ended March 31, 2008, Sangamo reported a consolidated net loss of $8.0 million, or $0.20 per share, compared to a net loss of $5.4 million, or $0.15 per share, for the same period in 2007. As of March 31, 2008, the company had cash, cash equivalents and short-term investments of $73.6 million.

Revenues for the first quarter of 2008 were $2.8 million, compared to $1.4 million for the same period in 2007. First quarter 2008 revenues were primarily from Sangamo's agreements with Dow AgroSciences and Sigma-Aldrich Corporation, research grants and enabling technology agreements in protein production.

Research and development expenses were $8.6 million for the first quarter of 2008, compared to $5.4 million for the same period in 2007. The increase in R&D expenses is primarily related to advancing Sangamo's ZFP Therapeutic(TM) clinical program in diabetic neuropathy and costs related to pre-IND programs in HIV/AIDS and glioblastoma, as well as increased personnel and laboratory supply expenses. Non-cash employee stock-based compensation included in research and development expenses totaled $0.9 million and $0.3 million in the 2008 and 2007 periods, respectively.

General and administrative expenses were $2.9 million for the first quarter of 2008, compared to $2.0 million for the corresponding 2007 period. The increase in general and administrative expenses was primarily due to increased personnel costs. Non-cash employee stock-based compensation included in general and administrative expenses totaled $0.9 million and $0.2 million in the 2008 and 2007 periods, respectively.

Total operating expenses for the first quarter of 2008 were $11.6 million, compared to $7.4 million for the same period in 2007.

Net interest and other income was $0.8 million for the first quarter of 2008, compared to $0.6 million for the same period in 2007, primarily due to higher average cash and investment balances.

    First Quarter 2008 Highlights
     --   Initiation of a Phase 2 stem cell mobilization clinical trial. The
          study is a randomized, single-blind, placebo-controlled, multi-
          center Phase 2 clinical trial of SB-509 (SB-509-703) in subjects
          with mild to moderate diabetic neuropathy (DN) and is designed to
          evaluate the pharmacokinetics of stem cell mobilization into the
          bloodstream after treatment. Circulating stem cells observed post
          treatment with SB-509 are highly enriched in cell types that mediate
          tissue repair.  In addition, early data suggests that SB-509
          treatment may mobilize between 100 to 1000-fold more cells than are
          typically being introduced into subjects in many of the ex vivo stem
          cell therapeutic approaches that are currently being tested.
          Ultimately, this phenomenon may also serve as a pharmacodynamic
          surrogate biomarker enabling a physician to easily monitor progress
          of this therapy for DN after SB-509 administration.
     --   Entry into a second Research and License Agreement with Genentech,
          Inc. and a new License Agreement with Open Monoclonal Technologies
          (OMT).  Sangamo's second agreement with Genentech is an expansion of
          an earlier agreement and includes modification of additional targets
          for potential improvement of production cell lines using our
          proprietary zinc finger DNA-binding protein nuclease (ZFN)
          technology. Sangamo also agreed to provide a non-exclusive,
          worldwide license to OMT for the commercial use of transgenic
          animals generated using our proprietary ZFN technology.  OMT is
          paying Sangamo an upfront license fee, payments upon the achievement
          of certain clinical development and commercial milestones, a share
          of payments received by OMT from sublicensees, and royalties on
          sales of any products developed using Sangamo's ZFP technology.
     --   Successful completion of a key research milestone as part of the
          joint Research and Commercial License Agreement between Dow
          AgroSciences LLC and Sangamo This milestone represents the
          successful application of Sangamo's ZFN technology in precision
          genome editing of a native plant gene with the aim of improving a
          valuable trait in canola, a crop central to Dow AgroSciences'
     --   Presentation of positive preclinical animal data from Sangamo's ZFP
          Therapeutic program for the treatment of glioblastoma multiforme
          (GBM). Data were presented in the New Approaches to Biological
          Therapy Session at the 2008 Annual Meeting of the American
          Association for Cancer Research (AACR) by Sangamo's collaborator
          Michael C.V. Jensen, M.D., Associate Chair, Division of Cancer
          Immunotherapeutics & Tumor Immunology, City of Hope.  The data
          demonstrated that treatment of T-cells, engineered to kill
          glioblastoma cells, with ZFNs specifically targeted to the
          glucocorticoid receptor (GR) gene results in the knockout of the GR
          gene creating glucocorticoid-resistant T-cells. These zetakine-
          positive, GR-negative T-cells kill glioblastoma cells in vitro.  In
          addition, data were presented from a mouse model of GBM
          demonstrating that these T-cells were capable of killing tumor cells
          in the animal in the presence of the glucocorticoid dexamethasone.
     --   Publication of data demonstrating the use of Sangamo's ZFN
          technology in a new approach for rapid generation of "knock-out"
          cell lines. Sigma-Aldrich Corporation and Sangamo announced the
          publication of work which was carried out in collaboration with
          scientists from Pfizer Inc and represents a significant advance in
          the specificity and efficiency of the production of "knock-out" cell
          lines.  Such cell lines are powerful tools that are widely used in
          research to identify a gene's function, in drug development to
          screen potential drug candidates and for production of recombinant
          proteins.  The data were published in the Proceedings of the
          National Academy of Sciences Early Edition online on March 21, 2008,
          http://www.pnas.org/cgi/content/abstract/0800940105v1 ("Targeted
          Gene Knockout in Mammalian Cells Using Engineered Zinc Finger
          Nucleases") and in the print edition of the journal. Sigma-Aldrich
          is Sangamo's exclusive licensee for this technology in the
          laboratory research reagent field.
     --   Nomination of Thomas G. Wiggans for election to Sangamo's Board of
          Directors. Mr. Wiggans was most recently the Chief Executive Officer
          of Connetics Corporation from 1994, and Chairman of the Board from
          January 2006, until December 2006 when Connetics Corporation was
          acquired by Stiefel Laboratories, Inc.  He has extensive senior
          management experience in the biotechnology industry in executive and
          board positions with a number of life sciences companies.  He will
          stand for election by shareholders, along with other board members
          standing for re-election, at Sangamo's Annual Meeting which will be
          held at 9:00 a.m. (PT) on Wednesday, June 4, 2008 at Sangamo's
          headquarters in Richmond, California.

Conference Call

Sangamo will host a conference call today at 5:00 p.m. ET, which will be open to the public. The call will also be webcast live and can be accessed via a link on the Sangamo BioSciences website in the Investor Relations section under "Events and Presentations" http://investor.sangamo.com/events.cfm. The webcast replay will also be available for two weeks after the call. During the conference call, the company will review these results, discuss other business matters, and provide forward-looking guidance.

The conference call dial-in numbers are 877-675-4749 for domestic callers and 719-325-4940 for international callers. The passcode for the call is 6274211. For those unable to listen in at the designated time, a conference call replay will be available for one week following the conference call, from approximately 8:00 p.m. ET on April 30, 2008 to 11:59 p.m. ET on May 7, 2008. The conference call replay numbers for domestic and international callers are 888-203-1112 and 719-457-0820 respectively. The conference ID number for the replay is 6274211.

About Sangamo

Sangamo BioSciences, Inc. is focused on the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. The most advanced ZFP Therapeutic(TM) development program is currently in Phase 2 clinical trials for evaluation of safety and clinical effect in patients with diabetic neuropathy. Phase 1 clinical trials are ongoing to evaluate a ZFP Therapeutic for peripheral artery disease. Other therapeutic development programs are focused on stem cell mobilization, ALS, cancer, HIV/AIDS, neuropathic pain, nerve regeneration, Parkinson's disease and monogenic diseases. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases (ZFN(TM)) for gene modification. Sangamo has established strategic partnerships with companies outside of the human therapeutic space including Dow AgroSciences, Sigma-Aldrich Corporation and several companies applying its ZFP Technology to enhance the production of protein pharmaceuticals. For more information about Sangamo, visit the company's web site at http://www.sangamo.com.

This press release contains forward-looking statements regarding Sangamo's current expectations. These forward looking statements include, without limitation, references to the research and development of ZFP TFs and ZFNs, clinical trials and therapeutic applications of Sangamo's ZFP technology platform, achievement of research milestones and objectives, strategic partnership with collaborators and anticipated amount of cash and cash equivalents. These statements are not guarantees of future performance and are subject to certain risks, uncertainties and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, the early stage of ZFP Therapeutic development, uncertainties related to the timing of initiation and completion of clinical trials, whether clinical trial results will validate and support the safety and efficacy of ZFP Therapeutics, and the ability to establish strategic partnerships. Further, there can be no assurance that the necessary regulatory approvals will be obtained or that Sangamo will be able to develop commercially viable gene based therapeutics. Actual results may differ from those projected in forward-looking statements due to risks and uncertainties that exist in the company's operations and business environments. These risks and uncertainties are described more fully in the company's' Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q as filed with the Securities and Exchange Commission. Forward-looking statements contained in this announcement are made as of this date and will not be updated.

    (in thousands, except per share data)
                                                     Quarter Ended March 31,
                                                     2008              2007
    Consolidated Statement of Operations Data:
    Total revenues                                  $2,765            $1,422
    Operating expenses:
      Research and development                       8,646             5,430
      General and administrative                     2,927             1,999
        Total operating expenses                    11,573             7,429
    Loss from operations                            (8,808)           (6,007)
    Interest and other income, net                     836               648
    Net loss                                       $(7,972)          $(5,359)
    Basic and diluted net loss per common share     $(0.20)           $(0.15)
    Shares used in computing basic and diluted net
     loss per common share                          40,489            35,057

                                                 March 31,        December 31,
                                                    2008              2007

    Cash, cash equivalents and short-term
     investments                                   $73,579           $81,412
    Total assets                                    76,742            83,900
    Total stockholders' equity                      66,457            72,122

SOURCE Sangamo BioSciences, Inc.


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