Institutional Ownership
Shareholders
| Shareholder | Holders | Value ($MM) | % O/S | Shares |
|---|---|---|---|---|
| Institution | 288 | 984.37 | 67.05 | 68,168,358 |
| Mutual Fund | 249 | 534.51 | 31.80 | 32,329,500 |
| Insider | 12 | 1.78 | 0.10 | 104,040 |
Rotation
| Shareholder | Holders | Value Chg ($MM) | % O/S | Share Change |
|---|---|---|---|---|
| Buyers | 166 | 231.99 | 15.49 | 15,745,048 |
| Sellers | 108 | -103.12 | 7.10 | -7,223,095 |
| Net | -- | 128.87 | 8.39 | 8,521,953 |
Concentration
| Value ($MM) | % O/S | Shares | |
|---|---|---|---|
| Total Inst. | 984.37 | 67.05 | 68,168,358 |
| Top 10 Inst. | 559.02 | 38.19 | 38,825,409 |
| Top 20 Inst. | 706.32 | 48.16 | 48,967,385 |
| Top 50 Inst. | 850.45 | 57.98 | 58,945,627 |
Style
| Holders | Value ($MM) | % Inst Shares | Shares | |
|---|---|---|---|---|
| Growth | 59 | 106.94 | 6.72 | 6,837,177 |
| Aggressive Growth | 4 | 4.07 | 0.26 | 266,316 |
| Core Growth | 41 | 96.66 | 6.03 | 6,129,356 |
| Growth | 14 | 6.20 | 0.43 | 441,505 |
| Income | 7 | 7.49 | 0.52 | 524,814 |
| Income Value | 3 | 6.59 | 0.46 | 464,124 |
| Yield | 4 | 0.90 | 0.06 | 60,690 |
| Index | 28 | 374.75 | 25.95 | 26,379,805 |
| Other | 94 | 387.53 | 26.52 | 26,965,975 |
| Broker Dealer | 15 | 57.15 | 3.96 | 4,024,666 |
| GARP | 36 | 153.22 | 10.59 | 10,765,112 |
| Hedge Fund | 40 | 171.54 | 11.59 | 11,780,640 |
| Specialty | 2 | 0.70 | 0.05 | 49,452 |
| VC/Private Equi | 1 | 4.91 | 0.34 | 346,105 |
| Value | 34 | 42.46 | 2.91 | 2,959,341 |
| Core Value | 27 | 27.69 | 1.89 | 1,918,696 |
| Deep Value | 7 | 14.78 | 1.02 | 1,040,645 |
Location: Global Region
| Holders | % O/S | Shares | Share Change | |
|---|---|---|---|---|
| North America | 223 | 60.21 | 61,216,778 | 7,406,049 |
| Europe | 42 | 6.33 | 6,434,235 | 3,044,851 |
| Asia | 10 | 0.15 | 151,434 | 83,358 |
| Africa | 1 | 0.01 | 11,201 | 11,201 |
Top Holders
| Holder | Shares Held | % O/S | Share Change | Filing Date |
|---|---|---|---|---|
| The Vanguard Group, Inc. | 8,163,823 | 8.03 | 1,220,399 | 6/30/18 |
| BlackRock Institutional Trust Company, N.A. | 7,335,878 | 7.22 | 1,219,676 | 6/30/18 |
| State Street Global Advisors (US) | 6,080,644 | 5.98 | 1,543,693 | 6/30/18 |
| Wasatch Advisors, Inc. | 4,058,167 | 3.99 | 365,186 | 6/30/18 |
| Fidelity Management & Research Company | 3,319,050 | 3.26 | -932,409 | 6/30/18 |
| Adage Capital Management, L.P. | 3,250,000 | 3.20 | 950,000 | 6/30/18 |
| Credit Suisse Asset Management | 1,899,908 | 1.87 | 1,870,000 | 8/31/18 |
| Credit Suisse Securities (USA) LLC | 1,768,741 | 1.74 | -165,924 | 6/30/18 |
| EcoR1 Capital, LLC | 1,509,671 | 1.48 | 1,509,671 | 6/30/18 |
| Nuveen LLC | 1,439,527 | 1.42 | -53,798 | 6/30/18 |
Top Holders: Mutual Funds
| Fund | Shares Held | % O/S | Share Change | Filing Date |
|---|---|---|---|---|
| SPDR S&P Biotech ETF | 4,529,367 | 4.45 | 404,451 | 9/30/18 |
| Vanguard Total Stock Market Index Fund | 2,602,172 | 2.56 | 24,583 | 9/30/18 |
| iShares Russell 2000 ETF | 2,230,428 | 2.19 | 72,349 | 9/30/18 |
| Fidelity Select Biotechnology Portfolio | 2,100,662 | 2.07 | -562,363 | 8/31/18 |
| Credit Suisse (Lux) Glb Digital Health Equity Fd | 1,870,000 | 1.84 | 1,870,000 | 7/31/18 |
| Vanguard Extended Market Index Fund | 1,366,064 | 1.34 | 69,826 | 9/30/18 |
| Vanguard Small-Cap Index Fund | 1,295,072 | 1.27 | 37,037 | 9/30/18 |
| Wasatch Small Cap Growth Fund | 1,195,813 | 1.18 | -15,296 | 6/30/18 |
| iShares NASDAQ Biotechnology ETF | 1,184,338 | 1.16 | 4,480 | 9/30/18 |
| iShares Russell 2000 Growth ETF | 972,396 | 0.96 | -21,375 | 9/30/18 |
* Insider values reflect direct beneficial ownership.
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