Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 252 873.79 69.97 80,908,056
Mutual Fund 417 490.44 38.90 44,323,246
Insider 14 1.45 0.11 128,546

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 135 188.88 15.16 17,535,510
Sellers 115 -92.69 7.92 -9,163,244
Net 96.18 7.24 8,372,266

Concentration

Value ($MM) % O/S Shares
Total Inst. 876.86 70.21 81,186,602
Top 10 Inst. 559.60 44.93 51,959,009
Top 20 Inst. 677.97 54.44 62,949,619
Top 50 Inst. 793.12 63.69 73,641,259

Style

Holders Value ($MM) % Inst Shares Shares
Growth 56 147.68 11.83 13,685,299
Aggressive Growth 5 4.45 0.36 412,422
Core Growth 40 93.16 7.47 8,635,588
Growth 11 50.07 4.01 4,637,289
Income 6 7.44 0.60 688,700
Income Value 3 6.84 0.55 634,820
Yield 3 0.60 0.05 53,880
Index 27 284.44 22.83 26,403,810
Other 80 250.31 20.04 23,149,375
Broker Dealer 17 29.74 2.39 2,761,162
GARP 32 140.44 11.29 13,042,875
Hedge Fund 29 79.29 6.29 7,267,530
Specialty 1 0.16 0.01 15,000
VC Private Equity 1 0.68 0.05 62,808
Value 35 150.74 12.02 13,900,130
Core Value 29 143.45 11.43 13,222,713
Deep Value 6 7.30 0.59 677,417

Location: Global Region

Holders % O/S Shares Share Value
North America 199 59.59 68,902,375 744,253,220
Europe 49 9.82 11,350,727 122,412,016
Asia / Pacific 15 0.56 646,849 7,113,131
Middle East 1 0.24 281,291 3,029,504
Africa 1 -- 5,360 51,134

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 11,039,985 9.54 6,726,532 6/30/19
The Vanguard Group, Inc. 8,309,161 7.18 596,573 6/30/19
BlackRock Institutional Trust Company, N.A. 8,140,032 7.04 760,182 6/30/19
Wasatch Advisors, Inc. 6,598,908 5.72 161,000 6/30/19
State Street Global Advisors (US) 5,347,908 4.62 -504,733 6/30/19
Bellevue Asset Management AG 3,650,000 3.16 1,000,000 6/30/19
Fidelity Management & Research Company 2,679,450 2.32 234,700 6/30/19
Credit Suisse Asset Management 2,328,179 2.01 3,837 6/30/19
Dimensional Fund Advisors, L.P. 1,958,404 1.69 441,744 6/30/19
Citadel LLC 1,906,982 1.65 1,650,290 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 3,650,000 3.16 2,300,000 6/30/19
Vanguard Total Stock Market Index Fund 3,334,900 2.88 1,772 6/30/19
SPDR S&P Biotech ETF 3,127,607 2.70 -757,787 6/30/19
Vanguard Explorer Fund 2,895,855 2.50 2,551,588 6/30/19
Fidelity Select Biotechnology Portfolio 2,688,942 2.32 -55,679 6/30/19
iShares Russell 2000 ETF 2,510,613 2.17 115,021 7/31/19
Credit Suisse (Lux) Glb Digital Health Equity Fd 2,250,000 1.95 -- 1/31/19
Vanguard Extended Market Index Fund 1,580,347 1.37 6,755 6/30/19
Vanguard Small-Cap Index Fund 1,497,220 1.29 8,694 6/30/19
Wasatch Small Cap Growth Fund 1,288,714 1.11 -- 6/30/19

* Insider values reflect direct beneficial ownership.

Copyright Thomson Reuters Corporation