Institutional Ownership
Shareholders
| Shareholder | Holders | Value ($MM) | % O/S | Shares |
|---|---|---|---|---|
| Institution | 274 | 810.54 | 67.60 | 69,009,909 |
| Mutual Fund | 255 | 422.85 | 34.88 | 35,605,445 |
| Insider | 13 | 1.84 | 0.12 | 118,923 |
Rotation
| Shareholder | Holders | Value Chg ($MM) | % O/S | Share Change |
|---|---|---|---|---|
| Buyers | 112 | 122.53 | 10.22 | 10,429,940 |
| Sellers | 169 | -141.50 | 10.99 | -11,224,885 |
| Net | -- | -18.96 | 0.77 | -794,945 |
Concentration
| Value ($MM) | % O/S | Shares | |
|---|---|---|---|
| Total Inst. | 810.54 | 67.60 | 69,009,909 |
| Top 10 Inst. | 445.92 | 37.32 | 38,100,689 |
| Top 20 Inst. | 571.52 | 48.04 | 49,041,485 |
| Top 50 Inst. | 708.27 | 59.44 | 60,687,113 |
Style
| Holders | Value ($MM) | % Inst Shares | Shares | |
|---|---|---|---|---|
| Growth | 63 | 113.92 | 9.45 | 9,650,219 |
| Aggressive Growth | 3 | 3.36 | 0.29 | 293,058 |
| Core Growth | 47 | 88.47 | 7.31 | 7,463,028 |
| Growth | 13 | 22.09 | 1.86 | 1,894,133 |
| Income | 6 | 6.14 | 0.52 | 534,174 |
| Income Value | 3 | 5.44 | 0.46 | 473,821 |
| Yield | 3 | 0.70 | 0.06 | 60,353 |
| Index | 28 | 296.31 | 25.27 | 25,799,562 |
| Other | 89 | 297.74 | 24.46 | 24,973,898 |
| Broker Dealer | 16 | 58.20 | 4.95 | 5,051,003 |
| GARP | 33 | 137.75 | 10.92 | 11,149,263 |
| Hedge Fund | 37 | 101.23 | 8.55 | 8,724,340 |
| Specialty | 3 | 0.57 | 0.05 | 49,292 |
| Value | 32 | 54.78 | 4.51 | 4,606,066 |
| Core Value | 26 | 48.05 | 3.95 | 4,027,570 |
| Deep Value | 6 | 6.73 | 0.57 | 578,496 |
Location: Global Region
| Holders | % O/S | Shares | Share Change | |
|---|---|---|---|---|
| North America | 196 | 57.78 | 58,991,047 | 1,703,845 |
| Europe | 49 | 8.73 | 8,912,692 | 1,768,749 |
| Asia | 14 | 0.44 | 452,981 | 284,577 |
| Africa | 2 | 0.34 | 348,634 | 337,433 |
Top Holders
| Holder | Shares Held | % O/S | Share Change | Filing Date |
|---|---|---|---|---|
| The Vanguard Group, Inc. | 7,595,252 | 7.44 | 117,561 | 12/31/18 |
| BlackRock Institutional Trust Company, N.A. | 7,468,110 | 7.32 | -17,046 | 12/31/18 |
| State Street Global Advisors (US) | 5,910,152 | 5.79 | -602,475 | 12/31/18 |
| Wasatch Advisors, Inc. | 5,078,738 | 4.97 | 534,142 | 12/31/18 |
| Fidelity Management & Research Company | 2,461,150 | 2.41 | -194,955 | 12/31/18 |
| Credit Suisse Securities (USA) LLC | 2,345,143 | 2.30 | 160,638 | 12/31/18 |
| Credit Suisse Asset Management | 2,285,108 | 2.24 | 155,200 | 12/31/18 |
| Wellington Management Company, LLP | 2,048,725 | 2.01 | 879,507 | 12/31/18 |
| Nuveen LLC | 1,558,311 | 1.53 | 118,784 | 9/30/18 |
| Bellevue Asset Management AG | 1,350,000 | 1.32 | 1,350,000 | 12/31/18 |
Top Holders: Mutual Funds
| Fund | Shares Held | % O/S | Share Change | Filing Date |
|---|---|---|---|---|
| SPDR S&P Biotech ETF | 3,947,821 | 3.87 | -581,546 | 12/31/18 |
| Vanguard Total Stock Market Index Fund | 2,694,131 | 2.64 | 91,959 | 12/31/18 |
| Fidelity Select Biotechnology Portfolio | 2,477,921 | 2.43 | -178,155 | 12/31/18 |
| Credit Suisse (Lux) Glb Digital Health Equity Fd | 2,250,000 | 2.20 | 150,000 | 12/31/18 |
| iShares Russell 2000 ETF | 2,209,678 | 2.16 | -36,369 | 1/31/19 |
| Vanguard Extended Market Index Fund | 1,402,226 | 1.37 | 36,162 | 12/31/18 |
| BB Biotech Fd | 1,350,000 | 1.32 | 1,350,000 | 12/31/18 |
| Vanguard Small-Cap Index Fund | 1,305,396 | 1.28 | 10,324 | 12/31/18 |
| iShares NASDAQ Biotechnology ETF | 1,128,461 | 1.11 | -16,978 | 1/31/19 |
| Wasatch Small Cap Growth Fund | 1,122,837 | 1.10 | -53,420 | 12/31/18 |
* Insider values reflect direct beneficial ownership.
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