Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 254 885.11 70.86 81,961,742
Mutual Fund 423 488.68 40.18 46,038,312
Insider 15 1.45 0.12 144,316

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 139 193.78 15.57 18,008,256
Sellers 116 -87.45 7.49 -8,658,450
Net 106.34 8.08 9,349,806

Concentration

Value ($MM) % O/S Shares
Total Inst. 888.18 71.11 82,256,058
Top 10 Inst. 559.60 44.92 51,959,009
Top 20 Inst. 677.97 54.42 62,949,619
Top 50 Inst. 798.53 64.09 74,132,793

Style

Holders Value ($MM) % Inst Shares Shares
Growth 58 151.98 12.18 14,088,395
Aggressive Growth 5 4.62 0.38 434,323
Core Growth 42 93.94 7.52 8,698,412
Growth 11 53.42 4.28 4,955,660
Income 6 7.38 0.59 688,209
Income Value 3 6.84 0.55 634,820
Yield 3 0.55 0.05 53,389
Index 28 287.32 23.07 26,683,458
Other 82 253.90 20.29 23,474,874
Broker Dealer 17 29.74 2.39 2,761,162
GARP 33 143.88 11.55 13,356,874
Hedge Fund 30 79.44 6.29 7,279,030
Specialty 1 0.16 0.01 15,000
VC Private Equity 1 0.68 0.05 62,808
Value 35 150.71 12.02 13,903,933
Core Value 29 143.41 11.43 13,226,516
Deep Value 6 7.30 0.59 677,417

Location: Global Region

Holders % O/S Shares Share Value
North America 200 59.90 69,292,103 748,123,844
Europe 48 10.30 11,913,427 128,600,766
Asia / Pacific 18 0.66 763,877 8,374,034
Middle East 1 0.24 281,291 3,029,504
Africa 1 -- 5,360 51,134

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 11,039,985 9.54 6,726,532 6/30/19
The Vanguard Group, Inc. 8,309,161 7.18 596,573 6/30/19
BlackRock Institutional Trust Company, N.A. 8,140,032 7.04 760,182 6/30/19
Wasatch Global Investors Inc 6,598,908 5.70 161,000 6/30/19
State Street Global Advisors (US) 5,347,908 4.62 -504,733 6/30/19
Bellevue Asset Management AG 3,650,000 3.16 1,000,000 6/30/19
Fidelity Management & Research Company 2,679,450 2.32 234,700 6/30/19
Credit Suisse Asset Management 2,328,179 2.01 3,837 6/30/19
Dimensional Fund Advisors, L.P. 1,958,404 1.69 441,744 6/30/19
Citadel LLC 1,906,982 1.65 1,650,290 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 3,650,000 3.16 2,300,000 6/30/19
Vanguard Total Stock Market Index Fund 3,337,961 2.89 703 8/31/19
Vanguard Explorer Fund 2,895,855 2.50 2,551,588 6/30/19
SPDR S&P Biotech ETF 2,656,541 2.30 -429,248 9/30/19
iShares Russell 2000 ETF 2,607,793 2.25 216,056 9/30/19
Fidelity Select Biotechnology Portfolio 2,563,821 2.22 -- 8/31/19
Credit Suisse (Lux) Digital Health Equity Fund 2,250,000 1.95 -- 1/31/19
Vanguard Extended Market Index Fund 1,660,146 1.44 39,126 8/31/19
Vanguard Small-Cap Index Fund 1,466,950 1.27 -10,987 8/31/19
Wasatch Small Cap Growth Fund 1,288,714 1.11 -- 6/30/19

* Insider values reflect direct beneficial ownership.

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