Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 292 795.80 59.53 84,196,301
Mutual Fund 271 302.08 21.90 30,684,808
Insider 18 4.34 0.34 476,434

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 120 86.89 6.49 9,174,907
Sellers 128 -61.29 4.69 -6,627,603
Net 25.60 1.80 2,547,304

Concentration

Value ($MM) % O/S Shares
Total Inst. 998.90 77.11 109,063,174
Top 10 Inst. 622.49 48.95 69,231,067
Top 20 Inst. 745.84 58.21 82,336,876
Top 50 Inst. 891.81 69.13 97,780,067

Style

Holders Value ($MM) % Inst Shares Shares
Growth 68 144.38 10.79 15,267,794
Aggressive Growth 5 4.60 0.34 486,498
Core Growth 51 95.16 7.11 10,059,209
Growth 12 44.62 3.34 4,722,087
Income 6 3.59 0.27 383,684
Income Value 3 3.39 0.25 358,718
Yield 3 0.20 0.02 24,966
Index 32 286.09 21.39 30,250,098
Other 95 298.17 22.29 31,524,264
Broker Dealer 21 37.81 2.83 4,003,142
GARP 34 125.12 9.34 13,204,706
Hedge Fund 38 133.78 10.01 14,161,390
Specialty 2 1.46 0.11 155,026
Value 38 43.79 3.27 4,624,838
Core Value 30 36.98 2.76 3,908,560
Deep Value 8 6.81 0.51 716,278

Location: Global Region

Holders % O/S Shares Share Value
North America 242 67.47 95,431,301 869,411,200
Europe 54 9.30 13,148,459 124,615,572
Asia / Pacific 14 0.36 503,837 5,056,803
Africa 1 0.01 9,795 81,984

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Biogen Inc 24,420,157 17.27 24,420,157 4/8/20
BlackRock Institutional Trust Company, N.A. 8,638,013 6.11 -358,086 9/30/20
The Vanguard Group, Inc. 8,126,559 5.75 -345,336 9/30/20
Wasatch Global Investors Inc 7,108,935 5.03 355,792 9/30/20
State Street Global Advisors (US) 7,025,167 4.97 536,249 9/30/20
Bellevue Asset Management AG 3,850,000 2.72 -- 9/30/20
Two Sigma Investments, LP 3,143,165 2.22 -85,025 9/30/20
Credit Suisse Asset Management 2,866,439 2.03 155,400 9/30/20
Dimensional Fund Advisors, L.P. 2,293,798 1.62 35,910 9/30/20
Geode Capital Management, L.L.C. 1,758,834 1.24 -13,668 9/30/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 4,827,108 3.41 200,424 10/31/20
BB Biotech Fd 3,850,000 2.72 -- 9/30/20
Vanguard Total Stock Market Index Fund 3,190,907 2.26 21,263 10/31/20
Credit Suisse (Lux) Digital Health Equity Fund 2,800,000 1.98 -- 9/30/20
Wasatch Ultra Growth Fund 2,443,267 1.73 351,618 9/30/20
iShares Russell 2000 ETF 2,439,408 1.72 82,260 10/31/20
Vanguard Extended Market Index Fund 1,521,773 1.08 -141,017 10/31/20
Wasatch Small Cap Growth Fund 1,474,647 1.04 50,476 9/30/20
iShares NASDAQ Biotechnology ETF 1,387,492 0.98 46,982 10/31/20
Vanguard Small-Cap Index Fund 1,311,676 0.93 -5,690 10/31/20

* Insider values reflect direct beneficial ownership.

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