Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 267 493.36 54.29 76,489,504
Mutual Fund 229 256.04 23.39 28,678,437
Insider 17 4.20 0.33 461,434

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 142 286.03 26.88 37,863,683
Sellers 126 -122.00 13.21 -18,616,994
Net 164.04 13.66 19,246,689

Concentration

Value ($MM) % O/S Shares
Total Inst. 696.77 71.95 101,371,095
Top 10 Inst. 458.48 46.24 65,151,047
Top 20 Inst. 545.60 55.95 78,826,927
Top 50 Inst. 635.37 65.68 92,528,650

Style

Holders Value ($MM) % Inst Shares Shares
Growth 62 90.40 9.95 14,013,912
Aggressive Growth 5 3.45 0.38 541,056
Core Growth 46 57.79 6.31 8,893,645
Growth 11 29.17 3.25 4,579,211
Income 4 2.73 0.30 426,220
Income Value 2 2.59 0.29 406,233
Yield 2 0.14 0.01 19,987
Index 28 172.28 19.10 26,909,512
Other 84 190.57 20.98 29,557,650
Broker Dealer 17 18.67 2.08 2,926,572
GARP 36 72.89 7.88 11,095,630
Hedge Fund 29 98.80 11.00 15,502,790
Specialty 2 0.21 0.02 32,658
Value 38 21.28 2.21 3,109,404
Core Value 28 16.21 1.64 2,315,084
Deep Value 10 5.08 0.56 794,320

Location: Global Region

Holders % O/S Shares Share Value
North America 218 62.25 87,698,366 605,014,122
Europe 50 9.27 13,058,651 86,499,880
Asia / Pacific 15 0.43 605,891 4,991,205
Africa 1 0.01 8,187 74,092

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Biogen Inc 24,420,157 17.33 24,420,157 4/8/20
The Vanguard Group, Inc. 8,554,638 6.07 66,134 3/31/20
BlackRock Institutional Trust Company, N.A. 8,284,387 5.88 -245,509 3/31/20
Wasatch Global Investors Inc 5,938,434 4.22 -1,548,583 3/31/20
State Street Global Advisors (US) 4,847,768 3.44 33,142 3/31/20
Bellevue Asset Management AG 3,850,000 2.73 -- 3/31/20
Credit Suisse Asset Management 2,717,669 1.93 309,087 3/31/20
EcoR1 Capital, LLC 2,308,079 1.64 2,308,079 3/31/20
Dimensional Fund Advisors, L.P. 2,196,935 1.56 12,353 3/31/20
Tang Capital Management, LLC 2,032,980 1.44 2,032,980 3/31/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 3,852,901 2.73 1,216,622 6/30/20
BB Biotech Fd 3,850,000 2.73 -- 3/31/20
Vanguard Total Stock Market Index Fund 3,291,675 2.34 -4,691 5/31/20
iShares Russell 2000 ETF 2,424,760 1.72 54,748 6/30/20
Credit Suisse (Lux) Digital Health Equity Fund 2,250,000 1.60 -- 1/31/19
Vanguard Extended Market Index Fund 1,706,503 1.21 21,058 5/31/20
Wasatch Ultra Growth Fund 1,617,910 1.15 552,520 3/31/20
Vanguard Small-Cap Index Fund 1,500,703 1.07 -9,261 5/31/20
iShares NASDAQ Biotechnology ETF 1,431,547 1.02 66,355 6/30/20
Wasatch Small Cap Growth Fund 1,381,294 0.98 -120,236 3/31/20

* Insider values reflect direct beneficial ownership.

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