Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 296 1,140.58 66.58 67,975,506
Mutual Fund 244 463.59 32.45 33,132,241
Insider 12 1.76 0.10 106,040

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 139 142.40 8.23 8,400,173
Sellers 146 -168.70 10.01 -10,217,629
Net -- -26.29 1.78 -1,817,456

Concentration

Value ($MM) % O/S Shares
Total Inst. 1,140.58 66.58 67,975,506
Top 10 Inst. 634.12 37.17 37,948,899
Top 20 Inst. 800.41 46.78 47,759,795
Top 50 Inst. 987.90 57.62 58,821,006

Style

Holders Value ($MM) % Inst Shares Shares
Growth 66 126.45 7.85 8,017,163
Aggressive Growth 4 5.54 0.32 327,192
Core Growth 48 113.25 7.08 7,229,488
Growth 14 7.67 0.45 460,483
Income 6 8.91 0.52 529,433
Income Value 3 7.95 0.46 468,852
Yield 3 0.96 0.06 60,581
Index 30 443.28 25.63 26,168,520
Other 90 424.06 24.55 25,064,110
Broker Dealer 16 75.34 4.35 4,444,863
GARP 36 182.46 10.58 10,802,304
Hedge Fund 35 159.67 9.24 9,428,409
Specialty 2 0.72 0.04 42,429
VC/Private Equi 1 5.87 0.34 346,105
Value 36 72.61 4.23 4,317,963
Core Value 28 50.36 2.94 3,005,670
Deep Value 8 22.24 1.29 1,312,293

Location: Global Region

Holders % O/S Shares Share Change
North America 223 58.86 60,093,149 1,157,143
Europe 49 7.19 7,337,622 856,470
Asia 11 0.18 179,391 69,441
Africa 1 0.01 8,634 -2,567

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BlackRock Institutional Trust Company, N.A. 7,485,156 7.33 149,278 9/30/18
The Vanguard Group, Inc. 7,477,691 7.32 -686,132 9/30/18
State Street Global Advisors (US) 6,512,627 6.38 431,983 9/30/18
Wasatch Advisors, Inc. 4,544,596 4.45 486,429 9/30/18
Fidelity Management & Research Company 2,656,105 2.60 -662,945 9/30/18
Credit Suisse Securities (USA) LLC 2,184,505 2.14 415,764 9/30/18
Credit Suisse Asset Management 2,129,908 2.09 -- 10/31/18
Casdin Capital, LLC 2,000,000 1.96 600,000 9/30/18
Nuveen LLC 1,558,311 1.53 118,784 9/30/18
Adage Capital Management, L.P. 1,400,000 1.37 -1,850,000 9/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 4,529,367 4.44 404,451 9/30/18
Vanguard Total Stock Market Index Fund 2,602,172 2.55 -- 10/31/18
Fidelity Select Biotechnology Portfolio 2,395,576 2.35 -260,500 10/31/18
iShares Russell 2000 ETF 2,290,509 2.24 60,081 11/30/18
Credit Suisse (Lux) Glb Digital Health Equity Fd 2,100,000 2.06 -- 10/31/18
Vanguard Extended Market Index Fund 1,368,056 1.34 1,992 10/31/18
Vanguard Small-Cap Index Fund 1,296,360 1.27 1,288 10/31/18
Wasatch Small Cap Growth Fund 1,176,257 1.15 -19,556 9/30/18
iShares NASDAQ Biotechnology ETF 1,138,147 1.11 -46,191 11/30/18
iShares Russell 2000 Growth ETF 923,174 0.90 -49,222 11/30/18

* Insider values reflect direct beneficial ownership.

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