Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 305 1,244.93 56.06 80,302,898
Mutual Fund 285 454.01 24.47 34,498,624
Insider 19 8.83 0.55 792,630

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 152 173.69 7.96 11,402,647
Sellers 139 -221.33 10.04 -14,382,203
Net -47.64 2.08 -2,979,556

Concentration

Value ($MM) % O/S Shares
Total Inst. 1,452.79 73.66 105,515,685
Top 10 Inst. 913.29 49.00 70,191,823
Top 20 Inst. 1,089.53 56.88 81,485,728
Top 50 Inst. 1,283.15 65.73 94,158,494

Style

Holders Value ($MM) % Inst Shares Shares
Growth 71 200.26 9.07 12,996,722
Aggressive Growth 4 7.42 0.33 475,388
Core Growth 56 179.20 8.13 11,647,196
Growth 11 13.64 0.61 874,138
Income 7 9.55 0.43 621,408
Income Value 3 5.35 0.24 342,858
Yield 4 4.20 0.19 278,550
Index 33 473.55 21.36 30,592,037
Other 90 460.83 20.65 29,585,962
Broker Dealer 24 80.81 3.62 5,189,289
GARP 32 230.15 10.31 14,764,166
Hedge Fund 32 148.55 6.67 9,547,931
Specialty 2 1.32 0.06 84,576
Value 42 62.31 2.81 4,029,171
Core Value 34 51.95 2.33 3,343,864
Deep Value 8 10.36 0.48 685,307

Location: Global Region

Holders % O/S Shares Share Value
North America 258 66.08 94,657,489 1,289,987,695
Europe 49 7.11 10,179,228 154,150,380
Asia / Pacific 16 0.45 641,940 8,147,064
Middle East 1 0.02 26,096 407,228
Africa 1 0.01 10,932 97,951

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Biogen Inc 24,420,157 17.05 24,420,157 4/8/20
Wasatch Global Investors Inc 10,072,381 7.03 2,963,446 12/31/20
BlackRock Institutional Trust Company, N.A. 8,667,915 6.05 29,902 12/31/20
The Vanguard Group, Inc. 8,453,658 5.90 327,099 12/31/20
State Street Global Advisors (US) 6,377,057 4.45 -648,110 12/31/20
Credit Suisse Asset Management 3,266,439 2.28 400,000 12/31/20
Two Sigma Investments, LP 2,667,798 1.86 -475,367 12/31/20
Dimensional Fund Advisors, L.P. 2,356,055 1.64 62,257 12/31/20
Goldman Sachs & Company, Inc. 2,095,526 1.46 603,595 12/31/20
Geode Capital Management, L.L.C. 1,814,837 1.27 56,003 12/31/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 4,348,275 3.04 239,850 2/28/21
BB Biotech Fd 3,850,000 2.69 -- 9/30/20
Wasatch Ultra Growth Fund 3,619,329 2.53 1,176,062 12/31/20
Vanguard Total Stock Market Index Fund 3,143,407 2.19 -65,606 12/31/20
iShares Russell 2000 ETF 2,807,433 1.96 141,050 2/28/21
Credit Suisse (Lux) Digital Health Equity Fund 2,800,000 1.95 -- 10/31/20
Wasatch Small Cap Growth Fund 2,129,110 1.49 654,463 12/31/20
JPMorgan Funds Thematics - Genetic Therapies 1,726,764 1.21 565,839 12/31/20
Vanguard Extended Market Index Fund 1,623,483 1.13 11,230 1/31/21
Vanguard Small-Cap Index Fund 1,355,583 0.95 -18,057 1/31/21

* Insider values reflect direct beneficial ownership.

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