Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 274 810.54 67.60 69,009,909
Mutual Fund 255 422.85 34.88 35,605,445
Insider 13 1.84 0.12 118,923

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 112 122.53 10.22 10,429,940
Sellers 169 -141.50 10.99 -11,224,885
Net -- -18.96 0.77 -794,945

Concentration

Value ($MM) % O/S Shares
Total Inst. 810.54 67.60 69,009,909
Top 10 Inst. 445.92 37.32 38,100,689
Top 20 Inst. 571.52 48.04 49,041,485
Top 50 Inst. 708.27 59.44 60,687,113

Style

Holders Value ($MM) % Inst Shares Shares
Growth 63 113.92 9.45 9,650,219
Aggressive Growth 3 3.36 0.29 293,058
Core Growth 47 88.47 7.31 7,463,028
Growth 13 22.09 1.86 1,894,133
Income 6 6.14 0.52 534,174
Income Value 3 5.44 0.46 473,821
Yield 3 0.70 0.06 60,353
Index 28 296.31 25.27 25,799,562
Other 89 297.74 24.46 24,973,898
Broker Dealer 16 58.20 4.95 5,051,003
GARP 33 137.75 10.92 11,149,263
Hedge Fund 37 101.23 8.55 8,724,340
Specialty 3 0.57 0.05 49,292
Value 32 54.78 4.51 4,606,066
Core Value 26 48.05 3.95 4,027,570
Deep Value 6 6.73 0.57 578,496

Location: Global Region

Holders % O/S Shares Share Change
North America 196 57.78 58,991,047 1,703,845
Europe 49 8.73 8,912,692 1,768,749
Asia 14 0.44 452,981 284,577
Africa 2 0.34 348,634 337,433

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 7,595,252 7.44 117,561 12/31/18
BlackRock Institutional Trust Company, N.A. 7,468,110 7.32 -17,046 12/31/18
State Street Global Advisors (US) 5,910,152 5.79 -602,475 12/31/18
Wasatch Advisors, Inc. 5,078,738 4.97 534,142 12/31/18
Fidelity Management & Research Company 2,461,150 2.41 -194,955 12/31/18
Credit Suisse Securities (USA) LLC 2,345,143 2.30 160,638 12/31/18
Credit Suisse Asset Management 2,285,108 2.24 155,200 12/31/18
Wellington Management Company, LLP 2,048,725 2.01 879,507 12/31/18
Nuveen LLC 1,558,311 1.53 118,784 9/30/18
Bellevue Asset Management AG 1,350,000 1.32 1,350,000 12/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 3,947,821 3.87 -581,546 12/31/18
Vanguard Total Stock Market Index Fund 2,694,131 2.64 91,959 12/31/18
Fidelity Select Biotechnology Portfolio 2,477,921 2.43 -178,155 12/31/18
Credit Suisse (Lux) Glb Digital Health Equity Fd 2,250,000 2.20 150,000 12/31/18
iShares Russell 2000 ETF 2,209,678 2.16 -36,369 1/31/19
Vanguard Extended Market Index Fund 1,402,226 1.37 36,162 12/31/18
BB Biotech Fd 1,350,000 1.32 1,350,000 12/31/18
Vanguard Small-Cap Index Fund 1,305,396 1.28 10,324 12/31/18
iShares NASDAQ Biotechnology ETF 1,128,461 1.11 -16,978 1/31/19
Wasatch Small Cap Growth Fund 1,122,837 1.10 -53,420 12/31/18

* Insider values reflect direct beneficial ownership.

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