Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 264 671.94 69.13 80,144,495
Mutual Fund 421 372.34 37.22 42,795,197
Insider 19 5.71 0.57 658,682

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 122 53.40 5.48 6,352,562
Sellers 120 -90.01 9.21 -10,687,329
Net -36.61 3.74 -4,334,767

Concentration

Value ($MM) % O/S Shares
Total Inst. 680.94 70.00 81,158,645
Top 10 Inst. 411.10 42.36 49,115,485
Top 20 Inst. 501.06 51.63 59,863,988
Top 50 Inst. 600.83 61.85 71,706,642

Style

Holders Value ($MM) % Inst Shares Shares
Growth 66 129.70 13.30 15,420,426
Aggressive Growth 6 4.10 0.42 489,401
Core Growth 48 86.32 8.83 10,237,768
Growth 12 39.28 4.05 4,693,257
Income 6 5.53 0.57 660,517
Income Value 3 5.12 0.53 611,774
Yield 3 0.41 0.04 48,743
Index 26 224.65 23.16 26,847,596
Other 78 190.73 19.63 22,753,503
Broker Dealer 18 27.58 2.84 3,295,035
GARP 34 112.88 11.60 13,453,343
Hedge Fund 23 49.71 5.12 5,937,905
Specialty 3 0.56 0.06 67,220
Sector Specific -- -- -- --
Value 36 95.43 9.79 11,354,971
Core Value 27 86.29 8.85 10,261,776
Deep Value 9 9.14 0.94 1,093,195

Location: Global Region

Holders % O/S Shares Share Value
North America 213 57.90 67,127,412 562,495,539
Europe 54 11.55 13,392,480 112,272,478
Asia / Pacific 16 0.55 634,754 6,108,672
Africa 1 0.01 8,187 74,092

Top Holders

Holder Shares Held % O/S Share Change Filing Date
BlackRock Institutional Trust Company, N.A. 8,529,896 7.36 -33,204 12/31/19
The Vanguard Group, Inc. 8,488,504 7.32 153,398 12/31/19
Wellington Management Company, LLP 7,746,382 6.68 -3,136,700 12/31/19
Wasatch Global Investors Inc 7,487,017 6.46 588,494 12/31/19
State Street Global Advisors (US) 4,814,626 4.15 -204,450 12/31/19
Bellevue Asset Management AG 3,850,000 3.32 200,000 12/31/19
Credit Suisse Asset Management 2,408,582 2.08 -25,050 12/31/19
Dimensional Fund Advisors, L.P. 2,184,582 1.88 60,398 12/31/19
Fidelity Management & Research Company 2,021,327 1.74 -422,223 12/31/19
Geode Capital Management, L.L.C. 1,584,569 1.37 51,601 12/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 3,850,000 3.32 200,000 12/31/19
Vanguard Total Stock Market Index Fund 3,326,804 2.87 6,384 2/29/20
Vanguard Explorer Fund 2,895,855 2.50 -- 12/31/19
iShares Russell 2000 ETF 2,530,446 2.18 101,307 2/29/20
SPDR S&P Biotech ETF 2,384,498 2.06 -39,846 2/29/20
Credit Suisse (Lux) Digital Health Equity Fund 2,250,000 1.94 -- 1/31/19
Vanguard Extended Market Index Fund 1,684,155 1.45 -1,619 2/29/20
Vanguard Small-Cap Index Fund 1,525,478 1.31 -23,193 2/29/20
Wasatch Small Cap Growth Fund 1,501,530 1.29 212,816 12/31/19
Fidelity Select Biotechnology Portfolio 1,493,927 1.29 -527,400 1/31/20

* Insider values reflect direct beneficial ownership.

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