Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 272 755.32 57.97 65,617,281
Mutual Fund 251 365.46 31.91 36,114,511
Insider 14 2.58 0.21 239,373

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 102 113.05 8.65 9,785,391
Sellers 147 -113.61 8.77 -9,927,770
Net -- -0.57 0.12 -142,379

Concentration

Value ($MM) % O/S Shares
Total Inst. 755.32 57.97 65,617,281
Top 10 Inst. 421.11 32.41 36,682,169
Top 20 Inst. 538.34 41.43 46,894,140
Top 50 Inst. 663.63 51.11 57,853,750

Style

Holders Value ($MM) % Inst Shares Shares
Growth 62 111.45 8.61 9,745,291
Aggressive Growth 4 4.41 0.34 384,291
Core Growth 46 84.34 6.49 7,346,411
Growth 12 22.70 1.78 2,014,589
Income 6 6.11 0.47 535,112
Income Value 3 5.44 0.42 473,821
Yield 3 0.67 0.05 61,291
Index 27 294.92 22.71 25,703,629
Other 88 250.51 19.19 21,719,454
Broker Dealer 16 31.09 2.39 2,707,811
GARP 32 118.05 9.05 10,247,118
Hedge Fund 37 100.81 7.70 8,715,233
Specialty 3 0.57 0.04 49,292
Value 32 52.98 4.02 4,545,773
Core Value 26 46.34 3.51 3,967,277
Deep Value 6 6.64 0.51 578,496

Location: Global Region

Holders % O/S Shares Share Change
North America 193 49.25 55,750,420 562,933
Europe 46 7.60 8,602,219 1,727,290
Asia 15 0.44 501,465 312,351
Africa 2 0.31 345,360 336,726

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 7,595,252 6.71 117,561 12/31/18
BlackRock Institutional Trust Company, N.A. 7,468,110 6.60 -17,046 12/31/18
State Street Global Advisors (US) 5,910,152 5.22 -602,475 12/31/18
Wasatch Advisors, Inc. 5,078,738 4.49 534,142 12/31/18
Fidelity Management & Research Company 2,461,150 2.17 -194,955 12/31/18
Credit Suisse Asset Management 2,328,128 2.06 155,200 12/31/18
Wellington Management Company, LLP 2,048,725 1.81 879,507 12/31/18
Bellevue Asset Management AG 1,350,000 1.19 1,350,000 12/31/18
Dimensional Fund Advisors, L.P. 1,239,110 1.09 1,017,573 12/31/18
Northern Trust Investments, Inc. 1,202,804 1.06 -6,051 12/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 3,885,394 3.43 -62,427 3/31/19
Vanguard Total Stock Market Index Fund 2,892,094 2.56 197,963 2/28/19
Fidelity Select Biotechnology Portfolio 2,444,721 2.16 -33,200 2/28/19
Credit Suisse (Lux) Glb Digital Health Equity Fd 2,250,000 1.99 -- 1/31/19
iShares Russell 2000 ETF 2,166,670 1.91 -79,377 3/31/19
Vanguard Extended Market Index Fund 1,431,505 1.26 29,279 2/28/19
BB Biotech Fd 1,350,000 1.19 1,350,000 12/31/18
Vanguard Small-Cap Index Fund 1,319,949 1.17 14,553 2/28/19
Wasatch Small Cap Growth Fund 1,122,837 0.99 -53,420 12/31/18
iShares NASDAQ Biotechnology ETF 1,065,045 0.94 -80,394 3/31/19

* Insider values reflect direct beneficial ownership.

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