Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 254 762.12 72.38 83,897,803
Mutual Fund 425 431.23 39.72 45,556,183
Insider 17 1.96 0.17 193,066

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 113 54.70 5.19 6,018,955
Sellers 114 -46.46 4.27 -4,954,972
Net 8.24 0.92 1,063,983

Concentration

Value ($MM) % O/S Shares
Total Inst. 767.25 72.85 84,440,869
Top 10 Inst. 475.48 45.32 52,539,768
Top 20 Inst. 573.15 54.63 63,331,655
Top 50 Inst. 686.41 65.41 75,827,832

Style

Holders Value ($MM) % Inst Shares Shares
Growth 61 131.23 12.45 14,437,431
Aggressive Growth 4 2.93 0.28 323,409
Core Growth 45 81.72 7.74 8,967,671
Growth 12 46.58 4.44 5,146,351
Income 6 6.15 0.59 680,100
Income Value 3 5.66 0.54 625,649
Yield 3 0.49 0.05 54,451
Index 26 244.02 23.26 26,960,559
Other 80 224.51 21.24 24,622,564
Broker Dealer 21 29.59 2.82 3,270,146
GARP 34 123.98 11.78 13,653,256
Hedge Fund 24 70.74 6.62 7,677,162
Specialty 1 0.20 0.02 22,000
VC Private Equity -- -- -- --
Value 36 126.96 12.07 13,989,930
Core Value 29 121.41 11.54 13,376,913
Deep Value 7 5.55 0.53 613,017

Location: Global Region

Holders % O/S Shares Share Value
North America 203 60.88 70,571,914 640,466,771
Europe 49 11.42 13,236,828 120,210,397
Asia / Pacific 17 0.54 624,022 6,485,108
Africa 1 0.01 8,105 87,291
Middle East -- -- -- --

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 10,883,082 9.39 -156,903 9/30/19
BlackRock Institutional Trust Company, N.A. 8,563,100 7.39 423,068 9/30/19
The Vanguard Group, Inc. 8,335,106 7.19 25,945 9/30/19
Wasatch Global Investors Inc 6,898,523 5.95 299,615 9/30/19
State Street Global Advisors (US) 5,019,076 4.33 -328,832 9/30/19
Bellevue Asset Management AG 3,650,000 3.15 -- 9/30/19
Fidelity Management & Research Company 2,443,550 2.11 -235,900 9/30/19
Credit Suisse Asset Management 2,433,632 2.10 105,453 9/30/19
Citadel LLC 2,189,515 1.89 282,533 9/30/19
Dimensional Fund Advisors, L.P. 2,124,184 1.83 165,780 9/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 3,650,000 3.15 -- 9/30/19
Vanguard Total Stock Market Index Fund 3,302,891 2.85 7,812 10/31/19
Vanguard Explorer Fund 2,895,855 2.50 -- 9/30/19
iShares Russell 2000 ETF 2,557,169 2.21 -50,624 10/31/19
SPDR S&P Biotech ETF 2,535,883 2.19 -120,658 10/31/19
Fidelity Select Biotechnology Portfolio 2,443,521 2.11 -- 10/31/19
Credit Suisse (Lux) Digital Health Equity Fund 2,250,000 1.94 -- 1/31/19
Vanguard Extended Market Index Fund 1,675,224 1.44 -2 10/31/19
Vanguard Small-Cap Index Fund 1,448,828 1.25 2,009 10/31/19
Wasatch Small Cap Growth Fund 1,288,714 1.11 -- 9/30/19

* Insider values reflect direct beneficial ownership.

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