Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 285 982.46 67.03 68,153,325
Mutual Fund 249 534.53 31.80 32,327,619
Insider 12 1.78 0.10 104,040

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 163 234.75 15.68 15,941,672
Sellers 109 -103.14 7.11 -7,224,646
Net -- 131.62 8.57 8,717,026

Concentration

Value ($MM) % O/S Shares
Total Inst. 982.46 67.03 68,153,325
Top 10 Inst. 559.02 38.19 38,825,409
Top 20 Inst. 706.32 48.16 48,967,385
Top 50 Inst. 848.70 57.97 58,941,197

Style

Holders Value ($MM) % Inst Shares Shares
Growth 59 105.19 6.72 6,832,747
Aggressive Growth 4 4.07 0.26 266,316
Core Growth 41 94.92 6.02 6,124,926
Growth 14 6.20 0.43 441,505
Income 7 7.49 0.52 524,814
Income Value 3 6.59 0.46 464,124
Yield 4 0.90 0.06 60,690
Index 28 374.71 25.94 26,378,962
Other 93 387.52 26.52 26,964,675
Broker Dealer 15 57.15 3.96 4,024,666
GARP 36 153.22 10.59 10,765,112
Hedge Fund 39 171.53 11.59 11,779,340
Specialty 2 0.70 0.05 49,452
VC/Private Equi 1 4.91 0.34 346,105
Value 33 42.43 2.91 2,957,341
Core Value 26 27.65 1.89 1,916,696
Deep Value 7 14.78 1.02 1,040,645

Location: Global Region

Holders % O/S Shares Share Change
North America 221 60.20 61,206,745 7,601,122
Europe 42 6.33 6,434,235 3,044,851
Asia 10 0.15 151,434 83,358
Africa 1 0.01 11,201 11,201

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 8,163,823 8.03 1,220,399 6/30/18
BlackRock Institutional Trust Company, N.A. 7,335,878 7.22 1,219,676 6/30/18
State Street Global Advisors (US) 6,080,644 5.98 1,543,693 6/30/18
Wasatch Advisors, Inc. 4,058,167 3.99 365,186 6/30/18
Fidelity Management & Research Company 3,319,050 3.26 -932,409 6/30/18
Adage Capital Management, L.P. 3,250,000 3.20 950,000 6/30/18
Credit Suisse Asset Management 1,899,908 1.87 1,870,000 8/31/18
Credit Suisse Securities (USA) LLC 1,768,741 1.74 -165,924 6/30/18
EcoR1 Capital, LLC 1,509,671 1.48 1,509,671 6/30/18
Nuveen LLC 1,439,527 1.42 -53,798 6/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 4,529,367 4.45 404,451 9/30/18
Vanguard Total Stock Market Index Fund 2,602,172 2.56 24,583 9/30/18
iShares Russell 2000 ETF 2,230,428 2.19 72,349 9/30/18
Fidelity Select Biotechnology Portfolio 2,100,662 2.07 -562,363 8/31/18
Credit Suisse (Lux) Glb Digital Health Equity Fd 1,870,000 1.84 1,870,000 7/31/18
Vanguard Extended Market Index Fund 1,366,064 1.34 69,826 9/30/18
Vanguard Small-Cap Index Fund 1,295,072 1.27 37,037 9/30/18
Wasatch Small Cap Growth Fund 1,195,813 1.18 -15,296 6/30/18
iShares NASDAQ Biotechnology ETF 1,184,338 1.16 4,480 9/30/18
iShares Russell 2000 Growth ETF 972,396 0.96 -21,375 9/30/18

* Insider values reflect direct beneficial ownership.

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