Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 253 646.39 58.26 67,205,383
Mutual Fund 409 400.78 36.57 39,758,515
Insider 16 5.00 0.34 389,817

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 113 94.82 8.54 9,851,233
Sellers 149 -101.30 8.82 -10,176,698
Net -6.48 0.28 -325,465

Concentration

Value ($MM) % O/S Shares
Total Inst. 651.66 58.64 67,646,047
Top 10 Inst. 399.58 36.31 41,884,665
Top 20 Inst. 492.81 44.78 51,657,751
Top 50 Inst. 579.48 52.57 60,641,524

Style

Holders Value ($MM) % Inst Shares Shares
Growth 59 110.31 9.94 11,463,797
Aggressive Growth 4 4.18 0.36 417,411
Core Growth 43 73.78 6.65 7,670,832
Growth 12 32.35 2.93 3,375,554
Income 6 5.93 0.54 623,384
Income Value 3 5.37 0.49 562,953
Yield 3 0.56 0.05 60,431
Index 28 248.26 22.55 26,011,718
Other 86 193.00 17.34 19,997,887
Broker Dealer 19 26.70 2.43 2,799,098
GARP 33 112.22 10.13 11,688,673
Hedge Fund 33 53.98 4.77 5,500,116
Specialty 1 0.10 0.01 10,000
VC Private Equity -- -- -- --
Value 34 67.57 6.00 6,923,325
Core Value 28 62.01 5.50 6,340,932
Deep Value 6 5.56 0.50 582,393

Location: Global Region

Holders % O/S Shares Share Value
North America 200 49.94 57,605,084 553,971,505
Europe 52 8.15 9,400,353 91,110,597
Asia / Pacific 16 0.52 603,304 6,307,644
Africa 1 -- 5,360 90,852
Middle East -- -- -- --

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 7,712,588 6.69 117,336 3/31/19
BlackRock Institutional Trust Company, N.A. 7,379,850 6.40 -88,260 3/31/19
Wasatch Advisors, Inc. 6,437,908 5.58 1,359,170 3/31/19
State Street Global Advisors (US) 5,852,641 5.07 -57,511 3/31/19
Wellington Management Company, LLP 4,313,453 3.74 2,264,728 3/31/19
Bellevue Asset Management AG 2,650,000 2.30 1,300,000 3/31/19
Fidelity Management & Research Company 2,444,750 2.12 -16,400 3/31/19
Credit Suisse Asset Management 2,324,342 2.01 -3,786 3/31/19
Dimensional Fund Advisors, L.P. 1,516,660 1.31 277,550 3/31/19
Geode Capital Management, L.L.C. 1,252,473 1.09 123,108 3/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 3,885,394 3.37 -62,427 3/31/19
Vanguard Total Stock Market Index Fund 3,333,128 2.89 -210 5/31/19
Fidelity Select Biotechnology Portfolio 2,476,697 2.15 31,976 4/30/19
Credit Suisse (Lux) Glb Digital Health Equity Fd 2,250,000 1.95 -- 1/31/19
iShares Russell 2000 ETF 2,040,718 1.77 -48,384 5/31/19
Vanguard Extended Market Index Fund 1,573,592 1.36 -10,007 5/31/19
Vanguard Small-Cap Index Fund 1,488,526 1.29 14,105 5/31/19
BB Biotech Fd 1,350,000 1.17 1,350,000 12/31/18
Wasatch Small Cap Growth Fund 1,288,714 1.12 165,877 3/31/19
Wasatch Core Growth Fund 1,202,934 1.04 245,550 3/31/19

* Insider values reflect direct beneficial ownership.

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