Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 254 762.04 72.45 83,986,136
Mutual Fund 417 423.48 39.89 45,822,396
Insider 17 2.12 0.17 193,066

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 113 56.99 5.41 6,267,239
Sellers 119 -47.50 4.39 -5,094,077
Net 9.49 1.01 1,173,162

Concentration

Value ($MM) % O/S Shares
Total Inst. 767.37 72.92 84,532,302
Top 10 Inst. 475.48 45.32 52,539,768
Top 20 Inst. 573.15 54.63 63,331,655
Top 50 Inst. 686.30 65.40 75,815,277

Style

Holders Value ($MM) % Inst Shares Shares
Growth 60 131.14 12.44 14,419,974
Aggressive Growth 4 2.93 0.28 323,080
Core Growth 43 81.60 7.72 8,945,546
Growth 13 46.61 4.44 5,151,348
Income 6 6.14 0.59 679,552
Income Value 3 5.66 0.54 625,649
Yield 3 0.48 0.05 53,903
Index 26 244.44 23.30 27,017,531
Other 80 224.33 21.31 24,700,369
Broker Dealer 21 30.64 2.92 3,386,134
GARP 35 120.99 11.43 13,256,026
Hedge Fund 22 67.83 6.48 7,517,309
Specialty 1 0.18 0.02 21,000
Sector Specific 1 4.71 0.45 519,900
Value 34 127.06 12.09 14,012,351
Core Value 27 121.04 11.50 13,337,389
Deep Value 7 6.02 0.58 674,962

Location: Global Region

Holders % O/S Shares Share Value
North America 204 61.10 70,836,090 641,415,780
Europe 49 11.31 13,113,737 120,067,794
Asia / Pacific 16 0.49 571,188 5,775,361
Africa 1 0.01 8,187 74,092

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Wellington Management Company, LLP 10,883,082 9.39 -156,903 9/30/19
BlackRock Institutional Trust Company, N.A. 8,563,100 7.39 423,068 9/30/19
The Vanguard Group, Inc. 8,335,106 7.19 25,945 9/30/19
Wasatch Global Investors Inc 6,898,523 5.95 299,615 9/30/19
State Street Global Advisors (US) 5,019,076 4.33 -328,832 9/30/19
Bellevue Asset Management AG 3,650,000 3.15 -- 9/30/19
Fidelity Management & Research Company 2,443,550 2.11 -235,900 9/30/19
Credit Suisse Asset Management 2,433,632 2.10 105,453 9/30/19
Citadel LLC 2,189,515 1.89 282,533 9/30/19
Dimensional Fund Advisors, L.P. 2,124,184 1.83 165,780 9/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
BB Biotech Fd 3,650,000 3.15 -- 9/30/19
Vanguard Total Stock Market Index Fund 3,312,218 2.86 8,064 12/31/19
Vanguard Explorer Fund 2,895,855 2.50 -- 9/30/19
iShares Russell 2000 ETF 2,632,991 2.27 -14,661 12/31/19
Fidelity Select Biotechnology Portfolio 2,419,027 2.09 -24,494 11/30/19
SPDR S&P Biotech ETF 2,408,787 2.08 -265,187 12/31/19
Credit Suisse (Lux) Digital Health Equity Fund 2,250,000 1.94 -- 1/31/19
Vanguard Extended Market Index Fund 1,699,649 1.47 6,990 12/31/19
Vanguard Small-Cap Index Fund 1,537,724 1.33 86,628 12/31/19
Wasatch Small Cap Growth Fund 1,288,714 1.11 -- 9/30/19

* Insider values reflect direct beneficial ownership.

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