Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 274 758.44 64.29 65,754,428
Mutual Fund 252 395.09 35.18 35,975,772
Insider 14 3.02 0.23 237,373

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 102 111.73 9.45 9,668,217
Sellers 171 -144.06 11.35 -11,606,179
Net -- -32.33 1.90 -1,937,962

Concentration

Value ($MM) % O/S Shares
Total Inst. 758.44 64.29 65,754,428
Top 10 Inst. 421.11 35.87 36,682,169
Top 20 Inst. 538.34 45.85 46,894,140
Top 50 Inst. 664.21 56.53 57,814,907

Style

Holders Value ($MM) % Inst Shares Shares
Growth 63 111.55 9.53 9,746,624
Aggressive Growth 4 4.41 0.38 384,291
Core Growth 47 85.17 7.25 7,412,676
Growth 12 21.97 1.91 1,949,657
Income 6 6.10 0.52 535,112
Income Value 3 5.44 0.46 473,821
Yield 3 0.66 0.06 61,291
Index 27 294.98 25.13 25,704,658
Other 88 250.73 21.24 21,719,454
Broker Dealer 16 31.09 2.65 2,707,811
GARP 32 118.06 10.02 10,247,118
Hedge Fund 37 101.02 8.52 8,715,233
Specialty 3 0.57 0.05 49,292
Value 31 52.59 4.39 4,493,266
Core Value 25 45.95 3.83 3,914,770
Deep Value 6 6.64 0.57 578,496

Location: Global Region

Holders % O/S Shares Share Change
North America 194 54.45 55,687,470 498,294
Europe 48 8.66 8,854,802 1,698,873
Asia 14 0.44 448,979 259,865
Africa 2 0.34 345,360 336,726

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 7,595,252 7.43 117,561 12/31/18
BlackRock Institutional Trust Company, N.A. 7,468,110 7.30 -17,046 12/31/18
State Street Global Advisors (US) 5,910,152 5.78 -602,475 12/31/18
Wasatch Advisors, Inc. 5,078,738 4.97 534,142 12/31/18
Fidelity Management & Research Company 2,461,150 2.41 -194,955 12/31/18
Credit Suisse Asset Management 2,328,128 2.28 155,200 12/31/18
Wellington Management Company, LLP 2,048,725 2.00 879,507 12/31/18
Bellevue Asset Management AG 1,350,000 1.32 1,350,000 12/31/18
Dimensional Fund Advisors, L.P. 1,239,110 1.21 1,017,573 12/31/18
Northern Trust Investments, Inc. 1,202,804 1.18 -6,051 12/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
SPDR S&P Biotech ETF 3,947,821 3.86 -581,546 12/31/18
Vanguard Total Stock Market Index Fund 2,892,094 2.83 197,963 2/28/19
Fidelity Select Biotechnology Portfolio 2,443,821 2.39 -34,100 1/31/19
Credit Suisse (Lux) Glb Digital Health Equity Fd 2,250,000 2.20 -- 1/31/19
iShares Russell 2000 ETF 2,142,862 2.10 -103,185 2/28/19
Vanguard Extended Market Index Fund 1,431,505 1.40 29,279 2/28/19
BB Biotech Fd 1,350,000 1.32 1,350,000 12/31/18
Vanguard Small-Cap Index Fund 1,319,949 1.29 14,553 2/28/19
Wasatch Small Cap Growth Fund 1,122,837 1.10 -53,420 12/31/18
iShares NASDAQ Biotechnology ETF 1,108,949 1.08 -36,490 2/28/19

* Insider values reflect direct beneficial ownership.

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