November 18, 2024

Alexander D. Macrae
Chief Executive Officer
Sangamo Therapeutics, Inc.
501 Canal Blvd.
Richmond, CA 94804

       Re: Sangamo Therapeutics, Inc.
           Registration Statement on Form S-3
           Filed November 12, 2024
           File No. 333-283179
Dear Alexander D. Macrae:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Doris Stacey Gama at 202-551-3188 with any questions.



                                                           Sincerely,

                                                           Division of
Corporation Finance
                                                           Office of Life
Sciences
cc:   Courtney Tygesson, Esq.