SANGAMO THERAPEUTICS, INC.

501 Canal Blvd.

Richmond, California 94804

November 18, 2024

VIA EDGAR

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn: Doris Stacey Gama

RE: Sangamo Therapeutics, Inc.

Registration Statement on Form S-3

File No. 333-283179

Acceleration Request

Requested Date: November 19, 2024

Requested Time: 5:00 p.m. Eastern Time

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Exchange Act of 1933, as amended, the undersigned registrant hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (File No. 333-283179) (the “Registration Statement”) to become effective at 5:00 p.m. Eastern Time on November 19, 2024, or as soon thereafter as is practicable.

Once the Registration Statement has been declared effective, please orally confirm that event with Chadwick Mills at (650) 843-5654 or Courtney Tygesson at (312) 881-6680 of Cooley LLP, counsel to the registrant.

[Signature page follows]

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