UNITED STATES
               SECURITIES AND EXCHANGE COMMISSION
                     WASHINGTON, D.C.  20549
                                
                                
                                
                          SCHEDULE 13G
                                
                                
                                
            Under the Securities Exchange Act of 1934
                                
                       (Amendment No.  )*
                                
                                
                    SANGAMO BIOSCIENCES, INC.
                        (Name of Issuer)
                                
                                
                          COMMON STOCK
                 (Title of Class of Securities)
                                
                                
                           800677106
                         (CUSIP Number)
                                
                                
                         December 31, 2007
     (Date of Event Which Requires Filing of this Statement)
                                
Check the appropriate box to designate the rule pursuant to which
this Schedule is filed:

     [ X ]  Rule 13d-1(b)
     [   ]  Rule 13d-1(c)
     [   ]  Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to
the subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided
in a prior cover page.

The information required in the remainder of this cover page
shall not be deemed to be "filed" for the purpose of Section 18
of the Securities Exchange Act of 1934 ("Act") or otherwise
subject to the liabilities of that section of the Act but shall
be subject to all other provisions of the Act (however, see the
Notes).


CUSIP No. 800677106    



1.  NAME OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOs. OF ABOVE PERSONS

                   HEARTLAND ADVISORS, INC.

                   #39-1078128

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                   (a)  [      ]
                                   (b)  [      ]

3.  SEC USE ONLY

4.  CITIZENSHIP OR PLACE OF ORGANIZATION

                             WISCONSIN, U.S.A.

-------------------------------------------------------------------
NUMBER OF        		5.  SOLE VOTING POWER
SHARES BENEFICIALLY   
OWNED BY              			None
EACH          
REPORTING        		6.  SHARED VOTING POWER
PERSON         
WITH                			2,300,000
                      
                      	7.  SOLE DISPOSITIVE POWER
                      
                           		None
                      
                      	8.  SHARED DISPOSITIVE POWER
                      
                            		2,300,000
-------------------------------------------------------------------

9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     2,300,000

10.  CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES  ____


11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     5.7%

12.  TYPE OF REPORTING PERSON

       IA


CUSIP No. 800677106

1.  NAME OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOs. OF ABOVE PERSONS

                   WILLIAM J. NASGOVITZ      
	 
2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

                                   (a)  [      ]
                                   (b)  [      ]

3.  SEC USE ONLY

4.  CITIZENSHIP OR PLACE OF ORGANIZATION

                             U.S.A.

-------------------------------------------------------------------
NUMBER OF        		5.  SOLE VOTING POWER
SHARES BENEFICIALLY   
OWNED BY                		None
EACH          
REPORTING        		6.  SHARED VOTING POWER
PERSON         
WITH                   			2,300,000
                      
                      	7.  SOLE DISPOSITIVE POWER
                      
                              	None
                      
                      	8.  SHARED DISPOSITIVE POWER
                      
                               	2,300,000
-------------------------------------------------------------------

9.  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     2,300,000

10.  CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES  ____


11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     5.7%

12.  TYPE OF REPORTING PERSON

      IN


Item 1.
(a) Name of Issuer: SANGAMO BIOSCIENCES, INC.

         (b) Address of Issuer's Principal Executive Offices:
                501 Canal Blvd, Suite A100
		    Richmond, California 94804

Item 2.
         (a) Name of Person Filing:   (1) Heartland Advisors, Inc. 
   
               			      (2) William J. Nasgovitz

         (b) Address of Principal Business Office:
             (1)    789 North Water Street	(2)  789 North Water Street
                    Milwaukee, WI  53202             Milwaukee, WI  53202

         (c) Citizenship:  Heartland Advisors is a Wisconsin corporation.
			   William J. Nasgovitz - U.S.A

         (d) Title of Class of Securities:  Common Stock

(e) CUSIP Number: 800677106

Item 3.   The persons filing this Schedule 13G are Heartland Advisors, 
Inc., an investment adviser registered with the SEC, and William J. 
Nasgovitz, President and principal shareholder of Heartland Advisors, 
Inc.  Mr. Nasgovitz joins in this filing pursuant to SEC staff positions 
authorizing certain individuals in similar situations to join in a filing 
with a controlled entity eligible to file on Schedule 13G.  The reporting 
persons do not admit that they constitute a group.

Item 4. Ownership.

(a)	Amount beneficially owned:

2,300,000 shares may be deemed beneficially owned within the meaning of Rule 
13d-3 of the Securities Exchange Act of 1934 by (1) Heartland Advisors, Inc. by 
virtue of its investment discretion and voting authority granted by certain 
clients, which may be revoked at any time; and (2) William J. Nasgovitz, as
a result of his ownership interest in Heartland Advisors, Inc.  Heartland 
Advisors, Inc. and Mr. Nasgovitz each specifically disclaim beneficial 
ownership of any shares reported on the Schedule. 

(b) Percent of Class: 5.7%

(c)  For information on voting and dispositive power with respect to the above 
listed shares, see Items 5-9 of the Cover Pages.

Item 5. Ownership of Five Percent or Less of a Class.

        Not Applicable.

Item 6. Ownership of more than Five Percent on Behalf of Another Person.

The clients of Heartland Advisors, Inc., a registered investment adviser, 
including an investment company registered under the Investment Company 
Act of 1940 and other managed accounts, have the right to receive or the 
power to direct the receipt of dividends and proceeds from the sale of 
shares included on this Schedule.  The Heartland Value Fund, a series of
the Heartland Group, Inc., a registered investment company, owns 2,200,000
shares or 5.5% of the class of securities reported herein.  Any remaining
shares disclosed in this filing are owned by various other accounts 
managed by Heartland Advisors, Inc. on a discretionary basis.  To the 
best of Heartland Advisors' knowledge, none of the other accounts own 
more than 5% of the outstanding stock.

Item 7. Identification and Classification of the Subsidiary Which Acquired 
        the Security Being Reported on By the Parent Holding Company.

        Not Applicable.

Item 8. Identification and Classification of Members of the Group.

        Not Applicable.

Item 9. Notice of Dissolution of Group.

        Not Applicable.

Item 10.  Certification.

         By signing below, the undersigned certify that, to the best of 
their knowledge and belief, the securities referred to above were acquired 
and are held in the ordinary course of business and were not acquired and 
are not held for the purpose of or with the effect of changing or influencing 
the control of the issuer of the securities and were not acquired and are not
held in connection with or as a participant in any transaction having that 
purpose or effect.

                            SIGNATURE

        After reasonable inquiry and to the best of my knowledge and belief, 
I certify that the information set forth in this statement is true, complete 
and correct.

DATE: February 8, 2008

WILLIAM J. NASGOVITZ               	HEARTLAND ADVISORS, INC.

By: /s/  PAUL T. BESTE			By: /s/ PAUL T. BESTE
       Paul T. Beste				Paul T. Beste
       As Attorney in Fact for			Chief Operating Officer
       William J. Nasgovitz

EXHIBIT INDEX

     Exhibit 1       Joint Filing Agreement


EXHIBIT 1



                     Joint Filing Agreement
                                
                                
The undersigned persons agree and consent to the joint filing on
their behalf of this Schedule 13G in connection with their
beneficial ownership of SANGAMO BIOSCIENCES, INC. at December 31, 2007.




WILLIAM J. NASGOVITZ

By: /s/   PAUL T. BESTE
    Paul T. Beste
    As Attorney in Fact for William J. Nasgovitz





HEARTLAND ADVISORS, INC.


By:  /s/ PAUL T. BESTE
     Paul T. Beste
     Chief Operating Officer