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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* -------- Sangamo Biosciences, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 800677106 (CUSIP Number) December 31, 2003 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [x] Rule 13d-1(b) [ ] Rule 13d-1(c) [ ] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). Page 1 of 10 pages - ------------------- ------------------ CUSIP No. 800677106 13G Page 2 of 10 Pages - ------------------- ------------------ - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Columbia Wanger Asset Management, L.P. 36-3820584 - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* Not Applicable (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER None SHARES ------------------------------------------------------------ BENEFICIALLY 6 SHARED VOTING POWER 1,700,000 OWNED BY ------------------------------------------------------------ 7 SOLE DISPOSITIVE POWER EACH None REPORTING ------------------------------------------------------------ 8 SHARED DISPOSITIVE POWER PERSON WITH 1,700,000 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,700,000 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* Not Applicable [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 6.9 % - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IA - -------------------------------------------------------------------------------- - ------------------- ------------------ CUSIP No. 800677106 13G Page 3 of 10 Pages - ------------------- ------------------ - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON WAM Acquisition GP, Inc. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* Not Applicable (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER None SHARES ------------------------------------------------------------ BENEFICIALLY 6 SHARED VOTING POWER 1,700,000 OWNED BY ------------------------------------------------------------ 7 SOLE DISPOSITIVE POWER EACH None REPORTING ------------------------------------------------------------ 8 SHARED DISPOSITIVE POWER PERSON WITH 1,700,000 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,700,000 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* Not Applicable [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 6.9 % - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* CO - -------------------------------------------------------------------------------- - ------------------- ------------------ CUSIP No. 800677106 13G Page 4 of 10 Pages - ------------------- ------------------ - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Columbia Acorn Trust - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* Not Applicable (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Massachusetts - -------------------------------------------------------------------------------- NUMBER OF 5 SOLE VOTING POWER None SHARES ------------------------------------------------------------ BENEFICIALLY 6 SHARED VOTING POWER 1,600,000 OWNED BY ------------------------------------------------------------ 7 SOLE DISPOSITIVE POWER EACH None REPORTING ------------------------------------------------------------ 8 SHARED DISPOSITIVE POWER PERSON WITH 1,600,000 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,600,000 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* Not Applicable [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 6.4 % - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IV - -------------------------------------------------------------------------------- Item 1(a) Name of Issuer: Sangamo Biosciences, Inc. Item 1(b) Address of Issuer's Principal Executive Offices: 501 Canal Blvd., Suite A100 Richmond, California 94804 Item 2(a) Name of Person Filing: Columbia Wanger Asset Management, L.P. ("WAM") WAM Acquisition GP, Inc., the general partner of WAM ("WAM GP") Columbia Acorn Trust ("Acorn") Item 2(b) Address of Principal Business Office: WAM, WAM GP, and Acorn are all located at: 227 West Monroe Street, Suite 3000 Chicago, Illinois 60606 Item 2(c) Citizenship: WAM is a Delaware limited partnership; WAM GP is a Delaware corporation; and Acorn is a Massachusetts business trust. Item 2(d) Title of Class of Securities: Common Stock Item 2(e) CUSIP Number: 800677106 Item 3 Type of Person: (d) Acorn is an Investment Company under section 8 of the Investment Company Act. (e) WAM is an Investment Adviser registered under section 203 of the Investment Advisers Act of 1940; WAM GP is the General Partner of the Investment Adviser. Page 5 of 10 pages Item 4 Ownership (at December 31, 2003): (a) Amount owned "beneficially" within the meaning of rule 13d-3: 1,700,000 (b) Percent of class: 6.9 % (based on 24,814,486 shares outstanding as of September 30, 2003) (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: none (ii) shared power to vote or to direct the vote: 1,700,000 (iii) sole power to dispose or to direct the disposition of: none (iv) shared power to dispose or to direct disposition of: 1,700,000 Item 5 Ownership of Five Percent or Less of a Class: Not Applicable Item 6 Ownership of More than Five Percent on Behalf of Another Person: The shares reported herein have been acquired on behalf of discretionary clients of WAM, including Acorn. Persons other than WAM and WAM GP are entitled to receive all dividends from, and proceeds from the sale of, those shares. Acorn is the only such person known to be entitled to all dividends from, and all proceeds from the sale of, shares reported herein to the extent of more than 5% of the class. Item 7 Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company: Not Applicable Item 8 Identification and Classification of Members of the Group: Not Applicable Item 9 Notice of Dissolution of Group: Not Applicable Page 6 of 10 pages Item 10 Certification: By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. Page 7 of 10 pages Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: February 13, 2004 The undersigned corporation, on the date above written, agrees and consents to the joint filing on its behalf of this Schedule 13G in connection with its beneficial ownership of the security reported herein. WAM Acquisition GP, Inc. for itself and as general partner of COLUMBIA WANGER ASSET MANAGEMENT, L.P. By: /s/ Bruce H. Lauer ---------------------------------------- Bruce H. Lauer Senior Vice President and Secretary The undersigned trust, on the date above written, agrees and consents to the joint filing on its behalf of this Schedule 13G in connection with its beneficial ownership of the security reported herein. COLUMBIA ACORN TRUST By: /s/ Bruce H. Lauer ---------------------------------------- Bruce H. Lauer Vice President, Treasurer and Secretary Page 8 of 10 pages Exhibit Index Exhibit 1 Joint Filing Agreement dated as of February 13, 2004 by and among Columbia Wanger Asset Management, L.P., WAM Acquisition GP, Inc., and Columbia Acorn Trust. Page 9 of 10 pages EXHIBIT 1 JOINT FILING AGREEMENT The undersigned hereby agree to the joint filing of the Schedule 13G to which this Agreement is attached. Dated: February 13, 2004 WAM Acquisition GP, Inc. for itself and as general partner of COLUMBIA WANGER ASSET MANAGEMENT, L.P. By: /s/ Bruce H. Lauer ---------------------------------------- Bruce H. Lauer Senior Vice President and Secretary COLUMBIA ACORN TRUST By: /s/ Bruce H. Lauer ---------------------------------------- Bruce H. Lauer Vice President, Treasurer and Secretary Page 10 of 10 pages