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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                    FORM 8-K

                             CURRENT REPORT Pursuant
                          to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

Date of report (Date of earliest event reported): January 4, 2005

                           SANGAMO BIOSCIENCES, INC.
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             (Exact Name of Registrant as Specified in Its Charter)

                                    Delaware
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                 (State or Other Jurisdiction of Incorporation)

               000-30171                             68-0359556
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       (Commission File Number)           (IRS Employer Identification No.)

         501 Canal Blvd, Suite A100              Richmond, California 94804
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  (Address of Principal Executive Offices)               (Zip Code)

                                 (510) 970-6000
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              (Registrant's Telephone Number, Including Area Code)

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          (Former Name or Former Address, if Changed Since Last Report)

     Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

     [ ]  Written communications pursuant to Rule 425 under the Securities Act
          (17 CFR 230.425)

     [ ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
          CFR 240.14a-12)

     [ ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the
          Exchange Act (17 CFR 240.14d-2(b))

     [ ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the
          Exchange Act (17 CFR 240.13e-4(c))

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ITEM 8.01 OTHER EVENTS On January 04, 2005, Sangamo BioSciences Inc. issued a press release announcing appointment of David Ichikawa as Senior Vice President, Business Development. Mr. Ichikawa will have responsibility for all licensing and business development activities for the company and will report to Edward Lanphier, Sangamo's president and chief executive officer. A copy of the press release issued by Sangamo BioSciences, Inc. relating to this event is filed as an exhibit to this Current Report on Form 8-K. ITEM 9.01 FINANCIAL STATEMENTS AND EXHIBITS (c) Exhibits. The following material is filed as an exhibit to this Current Report on Form 8-K: Exhibit No. 99.1 Press Release Issued January 4, 2005.

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. DATE: January 4, 2005 SANGAMO BIOSCIENCES, INC. By: /s/ EDWARD O. LANPHIER II ----------------------------------- Edward O. Lanphier II President, Chief Executive Officer

                                                                    Exhibit 99.1

         SANGAMO BIOSCIENCES ANNOUNCES THE APPOINTMENT OF DAVID ICHIKAWA
                 AS SENIOR VICE PRESIDENT, BUSINESS DEVELOPMENT

    POINT RICHMOND, Calif., Jan. 4 /PRNewswire-FirstCall/ -- Sangamo
BioSciences, Inc. (Nasdaq: SGMO) announced today the appointment of David
Ichikawa as Senior Vice President, Business Development.  Mr. Ichikawa will
have responsibility for all licensing and business development activities for
the company and will report to Edward Lanphier, Sangamo's president and chief
executive officer.

    "We are very pleased to have David join our management team," said Edward
Lanphier. "He brings significant experience in both operations and business
development from a successful career in the biotechnology industry and we expect
him to play a key role developing and implementing our strategy to secure the
commercial success of our ZFP Therapeutics."

    Mr. Ichikawa was most recently Chief Business Officer for Sagres Discovery,
where he was responsible for corporate strategy and business development
activities. While at Sagres he negotiated a major collaboration with Boehringer
Ingelheim, the strategic acquisition of MemRx Corporation and played a critical
role in the acquisition of Sagres by Chiron Corporation. He has more than 20
years of industry experience with both pharmaceutical and biotechnology
companies in various commercial areas. Prior to Sagres Discovery, David held
several positions with Chiron Corporation including Vice President, R&D Business
Development and Finance. Mr. Ichikawa earned his M.B.A. degree from the
University of California at Berkeley and a B.S. degree from the University of
California at Davis.

    "The power of Sangamo's proprietary ZFP technology lies in its versatility
and broad applicability. The ability to target specific DNA sequences in the
genome to achieve activation, repression or modification of therapeutically
relevant genes provides significant opportunities to develop novel
therapeutics," said Mr. Ichikawa. "Increasingly, pharmaceutical companies are
identifying 'validated targets' that prove to be 'non-druggable' using their
conventional small molecule drug and recombinant protein approaches. I believe
that Sangamo's technology will provide therapeutic approaches to such
intractable problems and allow us to address these unmet medical needs. I am
very pleased to be joining Sangamo and am looking forward to the opportunity to
lead efforts to develop and commercialize this novel technology."

    About Sangamo
    Sangamo BioSciences, Inc. is focused on the research and development of
novel DNA-binding proteins for therapeutic gene regulation and modification. The
company's most advanced therapeutic development program, currently in a Phase I
clinical trial, involves the use of transcription factors for the treatment of
peripheral artery disease. Other therapeutic development programs are focused on
diabetic neuropathy, ischemic heart disease, congestive heart failure, cancer,
neuropathic pain, and infectious and monogenic diseases. Sangamo's core
competencies enable the engineering of a class of DNA-binding proteins known as
zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a
specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TFs)
that can control gene expression and, consequently, cell

function. Sangamo is also developing sequence-specific ZFP-Nucleases (ZFNs) for therapeutic gene modification as a treatment and possible cure for a variety of monogenic diseases such as sickle cell anemia and for infectious diseases such as HIV. For more information about Sangamo, visit the company's web site at www.sangamo.com or www.expressinglife.com. This press release may contain forward-looking statements based on Sangamo's current expectations. These forward-looking statements include, without limitation, references to the research and development of novel ZFP TFs and applications of Sangamo's ZFP TF technology platform. Actual results may differ materially from these forward-looking statements due to a number of factors, including technological challenges, Sangamo's ability to develop commercially viable products and technological developments by our competitors. See the company's SEC filings, and in particular, the risk factors described in the company's Annual Report on Form 10-K and its most recent 10-Q. Sangamo BioSciences, Inc. assumes no obligation to update the forward-looking information contained in this press release. SOURCE Sangamo BioSciences, Inc. -0- 01/04/2005 /CONTACT: Elizabeth Wolffe, Ph.D, of Sangamo BioSciences, Inc., +1-510-970-6000, ext. 271, or ewolffe@sangamo.com; or media, Kathy Nugent, +1-212-213-0006, or investors, John Cummings, +1-415-532-6262, both of Burns McClellan, Inc., for Sangamo BioSciences, Inc./ /Web site: http://www.sangamo.com